Gregersen Lab

University of Copenhagen

Our Research

Correct regulation of transcription and accurate co-transcriptional mRNA processing is essential for gene expression.

Regulation of transcription is dependent on RNA polymerase II (RNAPII) modifications and its dynamic interaction with factors recognising specific modifications. Our work aims to understand the function of a class of Serine/Arginine (SR)-related and CTD-associated factors (SCAFs), which interact with the CTD of RNAPII.

Using a combination of molecular biology, state-of-the art transcriptomics and proteomics we aim to elucidate how transcription and co-transcriptional processing are regulated by RNAPII CTD associated factors.

This will provide new insights into the function of SCAF proteins in transcription – an area that is currently unexplored. Once we understand their role in transcription we can begin to understand how errors in transcriptional regulation and co-transcriptional processing contribute to disease development.

Lea Haarup Gregesen

Lea is an experimental biologist with more than 15 years’ experience in RNA biology and transcription.

She did her undergraduate studies in Biochemistry at the University of Copenhagen. After that she moved to Germany, where she did her PhD at the Berlin Institute for Medical Systems Biology (BIMSB) with Markus Landthaler. She then moved to the UK where she did her postdoc at the Francis Crick Institute in London under the supervision of Jesper Svejstrup, supported by an EMBO long-term fellowship. Here, she became fascinated by the coordination between transcription and RNA processing.

After more than 12 successful years abroad, Lea returned to Copenhagen where she set up her own research group in 2021. Her team is supported by a Novo Nordisk Foundation Hallas-Møller emerging investigation grant, by the Danish Council for Independent Research (Sapere Aude Research Leader Program) and the European Research Council (ERC starting grant).

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